NK19b-KR

General Information


DCTPep ID  DCTPep02523

Peptide Name   NK19b-KR

Sequence  RILRGVSRRIMRRILTGRR

Sequence Length  19

UniProt ID  Not available

PubChem CID  44576277 

Origin  Synthetic

Type  Synthetic peptide

Classification

  

Cancer targeted peptides Membrane lysis



Activity Information


Cell Line Disease Activity Assay Testing Time Literature
HeLa Human papillomavirus-related endocervical adenocarcinoma 6.6 ± 7.9% Cytotoxicity=100 μg/ml MTT assay 24 h 1

Hemolytic Activity  Human erythrocytes: <10% Hemolysis=100 µg/ml

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available



Structure Information


PDB ID  Not available

Predicted Structure  DCTPep02523

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Amidation

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C99H189N43O22S1

Absent amino acids  ACDEFHKNPQWY

Theoretical pI  12.85

Acidic residues  0

Basic residues  8

Polar residues  4

Molecular weight (Average)  2365.92

Molecular weight (Monoisotopic)  2364.47

Common amino acids  R

Net charge  8

Instability index (II)  127.56

Aliphatic index  117.89

Grand average of hydropathicity (GRAVY)  -0.584

Half Life 
  1 hours (mammalian reticulocytes, in vitro).
  2 min (yeast, in vivo).
  2 min (Escherichia coli, in vivo).

Extinction coefficients 
  Should not be visible by UV spectrophotometry.

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 17389605

Title  Rationale for the design of shortened derivatives of the NK-lysin-derived antimicrobial peptide NK-2 with improved activity against Gram-negative pathogens

Doi 10.1074/jbc.M608920200

Year  2007

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DBAASP ID  DBAASPS_5056

DCTPep is developed by Dr.Zheng's team.