Peptide Libraray

KLW

General Information

DCTPep ID DCTPep02531

Peptide Name KLW

Sequence KWKKLLKKLLKLLKKLLK

Sequence Length 18

UniProt ID Not available

PubChem CID Not available

Origin Synthetic

Type Synthetic peptide

Classification

ACP Tumor active peptide

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
A549	Lung adenocarcinoma	IC50=0.6 µM	SRB assay	3 days	1
SK-OV-3	Ovarian serous cystadenocarcinoma	IC50=0.6 µM	SRB assay	3 days	1
SK-MEL-2	Melanoma	IC50=0.7 µM	SRB assay	3 days	1

Hemolytic Activity Human erythrocytes: 55% Hemolysis=100 µM

Normal (non-cancerous) Cytotoxicity NIH 3T3: IC50=1.8 µM

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure DCTPep02531

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Amidation

Other Modification None

Chiral L

Physicochemical Information

Formula C113H208N28O19

Absent amino acids ACDEFGHIMNPQRSTVY

Theoretical pI 10.90

Acidic residues 0

Basic residues 9

Polar residues 0

Molecular weight (Average) 2263.07

Molecular weight (Monoisotopic) 2261.62

Common amino acids K

Net charge 9

Instability index (II) -28.29

Aliphatic index 173.33

Grand average of hydropathicity (GRAVY) -0.311

Half Life
1.3 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
3 min (Escherichia coli, in vivo).

Extinction coefficients
Ext. coefficient 5500
Abs 0.1% (=1 g/l) 2.430

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 16142907

Title Cell selectivity and mechanism of action of antimicrobial model peptides containing peptoid residues

Doi 10.1021/bi050765p

Year 2005

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available

External Code

DBAASP ID DBAASPS_5000