This work is licensed under a Creative Commons Attribution 4.0 International License.
KLW-L10-Nala
General Information
DCTPep ID DCTPep02533
Peptide Name KLW-L10-Nala
Sequence KWKKLLKKLXKLLKKLLK
Sequence Length 18
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
ACP Tumor active peptide
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| SK-OV-3 | Ovarian serous cystadenocarcinoma | IC50=0.9 µM | SRB assay | 3 days | 1 |
| A549 | Lung adenocarcinoma | IC50=1 µM | SRB assay | 3 days | 1 |
| SK-MEL-2 | Melanoma | IC50=1.3 µM | SRB assay | 3 days | 1 |
Hemolytic Activity Human erythrocytes: 23% Hemolysis=100 µM
Normal (non-cancerous) Cytotoxicity NIH 3T3: IC50=2 µM
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification X=NAla
Chiral L
Physicochemical Information
Formula Not Applicable
Absent amino acids Not Applicable
Theoretical pI Not Applicable
Acidic residues Not Applicable
Basic residues Not Applicable
Polar residues Not Applicable
Molecular weight (Average) Not Applicable
Molecular weight (Monoisotopic) Not Applicable
Common amino acids Not Applicable
Net charge Not Applicable
Instability index (II) Not Applicable
Aliphatic index Not Applicable
Grand average of hydropathicity (GRAVY) Not Applicable
Half Life
Not Applicable
Extinction coefficients
Not Applicable
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 16142907
Title Cell selectivity and mechanism of action of antimicrobial model peptides containing peptoid residues
Year 2005
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_5220
This work is licensed under a Creative Commons Attribution 4.0 International License.