KLW-L10-Nala

General Information


DCTPep ID  DCTPep02533

Peptide Name   KLW-L10-Nala

Sequence  KWKKLLKKLXKLLKKLLK

Sequence Length  18

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

ACP Tumor active peptide



Activity Information


Cell Line Disease Activity Assay Testing Time Literature
SK-OV-3 Ovarian serous cystadenocarcinoma IC50=0.9 µM SRB assay 3 days 1
A549 Lung adenocarcinoma IC50=1 µM SRB assay 3 days 1
SK-MEL-2 Melanoma IC50=1.3 µM SRB assay 3 days 1

Hemolytic Activity  Human erythrocytes: 23% Hemolysis=100 µM

Normal (non-cancerous) Cytotoxicity  NIH 3T3: IC50=2 µM

Target  Not available

Affinity  Not available

Mechanism  Not available



Structure Information


PDB ID  Not available

Predicted Structure  Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Amidation

Other Modification  X=NAla

Chiral  L



Physicochemical Information


Formula  Not Applicable

Absent amino acids  Not Applicable

Theoretical pI  Not Applicable

Acidic residues  Not Applicable

Basic residues  Not Applicable

Polar residues  Not Applicable

Molecular weight (Average)  Not Applicable

Molecular weight (Monoisotopic)  Not Applicable

Common amino acids  Not Applicable

Net charge  Not Applicable

Instability index (II)  Not Applicable

Aliphatic index  Not Applicable

Grand average of hydropathicity (GRAVY)  Not Applicable

Half Life 
  Not Applicable

Extinction coefficients 
  Not Applicable

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 16142907

Title  Cell selectivity and mechanism of action of antimicrobial model peptides containing peptoid residues

Doi 10.1021/bi050765p

Year  2005

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DBAASP ID  DBAASPS_5220

DCTPep is developed by Dr.Zheng's team.