This work is licensed under a Creative Commons Attribution 4.0 International License.
Cilengitide, EMD 121974
General Information
DCTPep ID DCTPep02537
Peptide Name Cilengitide, EMD 121974
Sequence RGDfX
Sequence Length 5
UniProt ID Not available
PubChem CID 176873
Origin RGD Fibronectin
Type Synthetic peptide
Classification
ACP Tumor active peptide Cancer targeted peptides Antiangiogenic Inhibitor of the integrins ανβ3 and ανβ5
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| M21 | Melanoma | IC50 (Cilengitide inhibited integrin-mediated binding to vitronectin) =0.4 µM | Lysosomal hexosaminidase quantitative assay | Not available | 1 |
| UCLA-P3 | Lung squamous cell carcinoma | IC50 (Cilengitide inhibited integrin-mediated binding to vitronectin) =0.4 µM | Lysosomal hexosaminidase quantitative assay | Not available | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Integrins αvβ3, αvβ5
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond NCB: Arg1<--->X5
N-terminal Modification Free
C-terminal Modification Free
Other Modification f=D-Phe
Chiral Mix
Physicochemical Information
Formula Not Applicable
Absent amino acids Not Applicable
Theoretical pI Not Applicable
Acidic residues Not Applicable
Basic residues Not Applicable
Polar residues Not Applicable
Molecular weight (Average) Not Applicable
Molecular weight (Monoisotopic) Not Applicable
Common amino acids Not Applicable
Net charge Not Applicable
Instability index (II) Not Applicable
Aliphatic index Not Applicable
Grand average of hydropathicity (GRAVY) Not Applicable
Half Life
Not Applicable
Extinction coefficients
Not Applicable
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 11855984
Title Nanomolar small molecule inhibitors for alphav(beta)6, alphav(beta)5, and alphav(beta)3 integrins
Year 2002
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.