Peptide Libraray

PenLys

General Information

DCTPep ID DCTPep02540

Peptide Name PenLys

Sequence KQIKIWFQNKKMKWKK

Sequence Length 16

UniProt ID Not available

PubChem CID 51032674

Origin Synthetic

Type Synthetic peptide

Classification

Cell-penetrating peptides

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
HeLa WT	Human papillomavirus-related endocervical adenocarcinoma	50% Cytotoxicity>1000 μM	MTS/PMS assay	1 h	1

Hemolytic Activity Human erythrocytes: HD50>128 μM

Normal (non-cancerous) Cytotoxicity Not available

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure DCTPep02540

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Amidation

Other Modification None

Chiral L

Physicochemical Information

Formula C104H168N28O20S1

Absent amino acids ACDEGHLPRSTVY

Theoretical pI 10.78

Acidic residues 0

Basic residues 7

Polar residues 1

Molecular weight (Average) 2162.71

Molecular weight (Monoisotopic) 2161.27

Common amino acids K

Net charge 7

Instability index (II) 48.74

Aliphatic index 48.75

Grand average of hydropathicity (GRAVY) -1.619

Half Life
1.3 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
3 min (Escherichia coli, in vivo).

Extinction coefficients
Ext. coefficient 11000
Abs 0.1% (=1 g/l) 5.086

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 23085001

Title Antimicrobial and cell-penetrating properties of penetratin analogs: effect of sequence and secondary structure

Doi 10.1016/j.bbamem.2012.10.010

Year 2013

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available

External Code

DBAASP ID DBAASPS_8799