PenLys

General Information


DCTPep ID  DCTPep02540

Peptide Name   PenLys

Sequence  KQIKIWFQNKKMKWKK

Sequence Length  16

UniProt ID  Not available

PubChem CID  51032674 

Origin  Synthetic

Type  Synthetic peptide

Classification

  

Cell-penetrating peptides



Activity Information


Cell Line Disease Activity Assay Testing Time Literature
HeLa WT Human papillomavirus-related endocervical adenocarcinoma 50% Cytotoxicity>1000 μM MTS/PMS assay 1 h 1

Hemolytic Activity  Human erythrocytes: HD50>128 μM

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available



Structure Information


PDB ID  Not available

Predicted Structure  DCTPep02540

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Amidation

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C104H168N28O20S1

Absent amino acids  ACDEGHLPRSTVY

Theoretical pI  10.78

Acidic residues  0

Basic residues  7

Polar residues  1

Molecular weight (Average)  2162.71

Molecular weight (Monoisotopic)  2161.27

Common amino acids  K

Net charge  7

Instability index (II)  48.74

Aliphatic index  48.75

Grand average of hydropathicity (GRAVY)  -1.619

Half Life 
  1.3 hours (mammalian reticulocytes, in vitro).
  3 min (yeast, in vivo).
  3 min (Escherichia coli, in vivo).

Extinction coefficients 
  Ext. coefficient 11000
  Abs 0.1% (=1 g/l) 5.086

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 23085001

Title  Antimicrobial and cell-penetrating properties of penetratin analogs: effect of sequence and secondary structure

Doi 10.1016/j.bbamem.2012.10.010

Year  2013

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DBAASP ID  DBAASPS_8799

DCTPep is developed by Dr.Zheng's team.