Peptide Libraray

PenShufLysLeu

General Information

DCTPep ID DCTPep02548

Peptide Name PenShufLysLeu

Sequence KWFKIQLQIKKWKNKK

Sequence Length 16

UniProt ID Not available

PubChem CID Not available

Origin Synthetic

Type Synthetic peptide

Classification

ACP Tumor active peptide Cell-penetrating peptides

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
HeLa WT	Human papillomavirus-related endocervical adenocarcinoma	50% Cytotoxicity=33 ± 8.5 μM	MTS/PMS assay	1 h	1

Hemolytic Activity Human erythrocytes: HD50=91 ± 2.3 μM

Normal (non-cancerous) Cytotoxicity Not available

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure DCTPep02548

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Amidation

Other Modification None

Chiral L

Physicochemical Information

Formula C105H170N28O20

Absent amino acids ACDEGHMPRSTVY

Theoretical pI 10.78

Acidic residues 0

Basic residues 7

Polar residues 1

Molecular weight (Average) 2144.68

Molecular weight (Monoisotopic) 2143.31

Common amino acids K

Net charge 7

Instability index (II) 24.54

Aliphatic index 73.12

Grand average of hydropathicity (GRAVY) -1.500

Half Life
1.3 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
3 min (Escherichia coli, in vivo).

Extinction coefficients
Ext. coefficient 11000
Abs 0.1% (=1 g/l) 5.129

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 23085001

Title Antimicrobial and cell-penetrating properties of penetratin analogs: effect of sequence and secondary structure

Doi 10.1016/j.bbamem.2012.10.010

Year 2013

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available

External Code

DBAASP ID DBAASPS_8806