AMP 1A analogs2

General Information


DCTPep ID  DCTPep02552

Peptide Name   AMP 1A analogs2

Sequence  GFXGXRXGXFXGXGRXRRRR

Sequence Length  20

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

ACP Tumor active peptide



Activity Information


Cell Line Disease Activity Assay Testing Time Literature
RL Diffuse large B-cell lymphoma IC50=1.1 μM CellTiter-Glo assay 72 h 1
NCI-H69 Lung small cell carcinoma; Small cell lung cancer IC50=2 μM CellTiter-Glo assay 72 h 1
CFPAC-1 Cystic fibrosis; Pancreatic ductal adenocarcinoma; Cystic fibrosis IC50=2.6 μM CellTiter-Glo assay 72 h 1
Mia PaCa-2 Pancreatic ductal adenocarcinoma IC50=5 μM CellTiter-Glo assay 72 h 1
A498 Renal cell carcinoma IC50=5.6 μM CellTiter-Glo assay 72 h 1
IGROV-1 Ovarian endometrioid adenocarcinoma; Endometrioid carcinoma of ovary IC50=6 μM CellTiter-Glo assay 72 h 1
A549 Lung adenocarcinoma IC50=6.4 μM CellTiter-Glo assay 72 h 1
DLD-1 Colon adenocarcinoma IC50=6.4 μM CellTiter-Glo assay 72 h 1
UACC-62 Melanoma IC50=6.4 μM CellTiter-Glo assay 72 h 1
COLO 205 Colon adenocarcinoma IC50=6.6 μM CellTiter-Glo assay 72 h 1
MCF-7 Invasive breast carcinoma of no special type IC50=7 μM CellTiter-Glo assay 72 h 1
PC-3 Prostate carcinoma IC50=7.4 μM CellTiter-Glo assay 72 h 1

Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available



Structure Information


PDB ID  Not available

Predicted Structure  Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Acetylation

C-terminal Modification  Amidation

Other Modification  X=A6c (1-aminocyclohexane carboxylic acid)

Chiral  L



Physicochemical Information


Formula  Not Applicable

Absent amino acids  Not Applicable

Theoretical pI  Not Applicable

Acidic residues  Not Applicable

Basic residues  Not Applicable

Polar residues  Not Applicable

Molecular weight (Average)  Not Applicable

Molecular weight (Monoisotopic)  Not Applicable

Common amino acids  Not Applicable

Net charge  Not Applicable

Instability index (II)  Not Applicable

Aliphatic index  Not Applicable

Grand average of hydropathicity (GRAVY)  Not Applicable

Half Life 
  Not Applicable

Extinction coefficients 
  Not Applicable

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 27387357

Title  Antibacterial and anticancer activity of a series of novel peptides incorporating cyclic tetra-substituted C(α) amino acids

Doi 10.1016/j.bmc.2016.06.048

Year  2016

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DBAASP ID  DBAASPS_9498

DCTPep is developed by Dr.Zheng's team.