This work is licensed under a Creative Commons Attribution 4.0 International License.
AMP 1A analogs2
General Information
DCTPep ID DCTPep02552
Peptide Name AMP 1A analogs2
Sequence GFXGXRXGXFXGXGRXRRRR
Sequence Length 20
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
ACP Tumor active peptide
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| RL | Diffuse large B-cell lymphoma | IC50=1.1 μM | CellTiter-Glo assay | 72 h | 1 |
| NCI-H69 | Lung small cell carcinoma; Small cell lung cancer | IC50=2 μM | CellTiter-Glo assay | 72 h | 1 |
| CFPAC-1 | Cystic fibrosis; Pancreatic ductal adenocarcinoma; Cystic fibrosis | IC50=2.6 μM | CellTiter-Glo assay | 72 h | 1 |
| Mia PaCa-2 | Pancreatic ductal adenocarcinoma | IC50=5 μM | CellTiter-Glo assay | 72 h | 1 |
| A498 | Renal cell carcinoma | IC50=5.6 μM | CellTiter-Glo assay | 72 h | 1 |
| IGROV-1 | Ovarian endometrioid adenocarcinoma; Endometrioid carcinoma of ovary | IC50=6 μM | CellTiter-Glo assay | 72 h | 1 |
| A549 | Lung adenocarcinoma | IC50=6.4 μM | CellTiter-Glo assay | 72 h | 1 |
| DLD-1 | Colon adenocarcinoma | IC50=6.4 μM | CellTiter-Glo assay | 72 h | 1 |
| UACC-62 | Melanoma | IC50=6.4 μM | CellTiter-Glo assay | 72 h | 1 |
| COLO 205 | Colon adenocarcinoma | IC50=6.6 μM | CellTiter-Glo assay | 72 h | 1 |
| MCF-7 | Invasive breast carcinoma of no special type | IC50=7 μM | CellTiter-Glo assay | 72 h | 1 |
| PC-3 | Prostate carcinoma | IC50=7.4 μM | CellTiter-Glo assay | 72 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Acetylation
C-terminal Modification Amidation
Other Modification X=A6c (1-aminocyclohexane carboxylic acid)
Chiral L
Physicochemical Information
Formula Not Applicable
Absent amino acids Not Applicable
Theoretical pI Not Applicable
Acidic residues Not Applicable
Basic residues Not Applicable
Polar residues Not Applicable
Molecular weight (Average) Not Applicable
Molecular weight (Monoisotopic) Not Applicable
Common amino acids Not Applicable
Net charge Not Applicable
Instability index (II) Not Applicable
Aliphatic index Not Applicable
Grand average of hydropathicity (GRAVY) Not Applicable
Half Life
Not Applicable
Extinction coefficients
Not Applicable
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 27387357
Title Antibacterial and anticancer activity of a series of novel peptides incorporating cyclic tetra-substituted C(α) amino acids
Year 2016
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_9498
This work is licensed under a Creative Commons Attribution 4.0 International License.