Peptide Libraray

peptide 1

General Information

DCTPep ID DCTPep02567

Peptide Name peptide 1

Sequence KKWWKKWWK

Sequence Length 9

UniProt ID Not available

PubChem CID Not available

Origin Synthetic

Type Synthetic peptide

Classification

ACP Tumor active peptide Membrane lysis

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
AT84	Murine squamous cell carcinoma	IC50=31.0 ± 1.0 µM	MTT assay	4 h	1
A20	Murine B cell lymphoma	IC50=37.3 ± 1.5 µM	MTT assay	4 h	1

Hemolytic Activity Not available

Normal (non-cancerous) Cytotoxicity MRC-5: IC50>357 µM

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Amidation

Other Modification None

Chiral L

Physicochemical Information

Formula C74H102N18O10

Absent amino acids ACDEFGHILMNPQRSTVY

Theoretical pI 10.60

Acidic residues 0

Basic residues 5

Polar residues 0

Molecular weight (Average) 1403.74

Molecular weight (Monoisotopic) 1402.8

Common amino acids K

Net charge 5

Instability index (II) 8.89

Aliphatic index 0.00

Grand average of hydropathicity (GRAVY) -2.567

Half Life
1.3 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
3 min (Escherichia coli, in vivo).

Extinction coefficients
Ext. coefficient 22000
Abs 0.1% (=1 g/l) 15.672

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 26982623

Title Discovery of a 9-mer Cationic Peptide (LTX-315) as a Potential First in Class Oncolytic Peptide

Doi 10.1021/acs.jmedchem.5b02025

Year 2016

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available

External Code

DBAASP ID DBAASPS_11875