Peptide Libraray

peptide 6

General Information

DCTPep ID DCTPep02571

Peptide Name peptide 6

Sequence KKWXKKWXK

Sequence Length 9

UniProt ID Not available

PubChem CID Not available

Origin Synthetic

Type Synthetic peptide

Classification

ACP Tumor active peptide Membrane lysis

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
A20	Murine B cell lymphoma	IC50=12 µM	MTT assay	4 h	1
AT84	Murine squamous cell carcinoma	IC50=15.0 ± 1.0 µM	MTT assay	4 h	1

Hemolytic Activity Not available

Normal (non-cancerous) Cytotoxicity MRC-5: IC50=80.0 ± 7.0 µM

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Amidation

Other Modification X=Dip (Diphenylalanine)

Chiral L

Physicochemical Information

Formula Not Applicable

Absent amino acids Not Applicable

Theoretical pI Not Applicable

Acidic residues Not Applicable

Basic residues Not Applicable

Polar residues Not Applicable

Molecular weight (Average) Not Applicable

Molecular weight (Monoisotopic) Not Applicable

Common amino acids Not Applicable

Net charge Not Applicable

Instability index (II) Not Applicable

Aliphatic index Not Applicable

Grand average of hydropathicity (GRAVY) Not Applicable

Half Life
Not Applicable

Extinction coefficients
Not Applicable

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 26982623

Title Discovery of a 9-mer Cationic Peptide (LTX-315) as a Potential First in Class Oncolytic Peptide

Doi 10.1021/acs.jmedchem.5b02025

Year 2016

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available

External Code

DBAASP ID DBAASPS_11895