PBP-W11

General Information


DCTPep ID  DCTPep02593

Peptide Name   PBP-W11

Sequence  KKLIKVFAKGWKKAKKLFKGIG

Sequence Length  22

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

ACP Tumor active peptide Membrane lysis



Activity Information


Cell Line Disease Activity Assay Testing Time Literature
HeLa Human papillomavirus-related endocervical adenocarcinoma 52% Cytotoxicity=15 µM CellTiter-Blue assay 24 h 1

Hemolytic Activity  Sheep erythrocytes: 0% Hemolysis=15 µM

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available



Structure Information


PDB ID  Not available

Predicted Structure  DCTPep02593

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C124H210N32O23

Absent amino acids  CDEHMNPQRSTY

Theoretical pI  10.90

Acidic residues  0

Basic residues  9

Polar residues  3

Molecular weight (Average)  2517.23

Molecular weight (Monoisotopic)  2515.62

Common amino acids  K

Net charge  9

Instability index (II)  -18.69

Aliphatic index  93.18

Grand average of hydropathicity (GRAVY)  -0.327

Half Life 
  1.3 hours (mammalian reticulocytes, in vitro).
  3 min (yeast, in vivo).
  3 min (Escherichia coli, in vivo).

Extinction coefficients 
  Ext. coefficient 5500
  Abs 0.1% (=1 g/l) 2.185

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 30637367

Title  Antimicrobial activity of a porphyrin binding peptide

Doi 110(4):e24074. doi: 10.1002/pep2.24074

Year  2018

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DBAASP ID  DBAASPS_12364

DCTPep is developed by Dr.Zheng's team.