Peptide Libraray

PBP-W18

General Information

DCTPep ID DCTPep02594

Peptide Name PBP-W18

Sequence KKLIKVFAKGFKKAKKLWKGIG

Sequence Length 22

UniProt ID Not available

PubChem CID Not available

Origin Synthetic

Type Synthetic peptide

Classification

ACP Tumor active peptide Membrane lysis

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
HeLa	Human papillomavirus-related endocervical adenocarcinoma	52% Cytotoxicity=15 µM	CellTiter-Blue assay	24 h	1

Hemolytic Activity Sheep erythrocytes: 0% Hemolysis=15 µM

Normal (non-cancerous) Cytotoxicity Not available

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure DCTPep02594

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Chiral L

Physicochemical Information

Formula C124H210N32O23

Absent amino acids CDEHMNPQRSTY

Theoretical pI 10.90

Acidic residues 0

Basic residues 9

Polar residues 3

Molecular weight (Average) 2517.23

Molecular weight (Monoisotopic) 2515.62

Common amino acids K

Net charge 9

Instability index (II) -13.54

Aliphatic index 93.18

Grand average of hydropathicity (GRAVY) -0.327

Half Life
1.3 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
3 min (Escherichia coli, in vivo).

Extinction coefficients
Ext. coefficient 5500
Abs 0.1% (=1 g/l) 2.185

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 30637367

Title Antimicrobial activity of a porphyrin binding peptide

Doi 110(4):e24074. doi: 10.1002/pep2.24074

Year 2018

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available

External Code

DBAASP ID DBAASPS_12365