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NRC-128
General Information
DCTPep ID DCTPep02611
Peptide Name NRC-128
Sequence GIRKWFKKAAHVGKKVGKVALNAYL
Sequence Length 25
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
ACP Tumor active peptide
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| HL-60 | Adult acute myeloid leukemia; Acute myeloid leukemia | 50% Cell death=64 µg/ml | MTT assay | 2 h | 1 |
Hemolytic Activity Human erythrocytes: 50% Hemolysis>256 µg/ml
Normal (non-cancerous) Cytotoxicity Zebrafish embryos: >10% Killing=5 µg/ml (28, 52hpf embryo); >10% Killing=25 µg/ml (4hpf embryo)
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure DCTPep02611
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C132H216N38O28
Absent amino acids CDEMPQST
Theoretical pI 10.75
Acidic residues 0
Basic residues 8
Polar residues 5
Molecular weight (Average) 2783.4
Molecular weight (Monoisotopic) 2781.66
Common amino acids K
Net charge 8
Instability index (II) -23.58
Aliphatic index 97.60
Grand average of hydropathicity (GRAVY) -0.132
Half Life
30 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 6990
Abs 0.1% (=1 g/l) 2.511
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 21729875
Title The zebrafish embryo as a tool for screening and characterizing pleurocidin host-defense peptides as anti-cancer agents
Year 2011
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_5365
This work is licensed under a Creative Commons Attribution 4.0 International License.