This work is licensed under a Creative Commons Attribution 4.0 International License.
Frenatin 2.1S
General Information
DCTPep ID DCTPep02614
Peptide Name Frenatin 2.1S
Sequence GLVGTLLGHIGKAILG
Sequence Length 16
UniProt ID Not available
PubChem CID Not available
Origin Sphaenorhynchus lacteus
Type Native peptide
Classification
ACP Tumor active peptide Immune system stimulating peptides
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| A549 | Lung adenocarcinoma | LC50=80 ± 6 μM | CellTiter-Glo Luminescent Cell Viability assay | 24 h | 1 |
Hemolytic Activity Human erythrocytes: HC50=167 ± 8 µM
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure DCTPep02614
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C70H123N19O18
Absent amino acids CDEFMNPQRSWY
Theoretical pI 8.76
Acidic residues 0
Basic residues 2
Polar residues 6
Molecular weight (Average) 1518.86
Molecular weight (Monoisotopic) 1517.93
Common amino acids G
Net charge 2
Instability index (II) 32.96
Aliphatic index 170.62
Grand average of hydropathicity (GRAVY) 1.275
Half Life
30 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).
Extinction coefficients
Should not be visible by UV spectrophotometry.
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 24704757
Title A family of antimicrobial and immunomodulatory peptides related to the frenatins from skin secretions of the Orinoco lime frog Sphaenorhynchus lacteus (Hylidae)
Doi 10.1016/j.peptides.2014.03.020
Year 2014
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPR_5369
This work is licensed under a Creative Commons Attribution 4.0 International License.