Frenatin 2.1S

General Information


DCTPep ID  DCTPep02614

Peptide Name   Frenatin 2.1S

Sequence  GLVGTLLGHIGKAILG

Sequence Length  16

UniProt ID  Not available

PubChem CID  Not available

Origin  Sphaenorhynchus lacteus

Type  Native peptide

Classification

  

ACP Tumor active peptide Immune system stimulating peptides



Activity Information


Cell Line Disease Activity Assay Testing Time Literature
A549 Lung adenocarcinoma LC50=80 ± 6 μM CellTiter-Glo Luminescent Cell Viability assay 24 h 1

Hemolytic Activity  Human erythrocytes: HC50=167 ± 8 µM

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available



Structure Information


PDB ID  Not available

Predicted Structure  DCTPep02614

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Amidation

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C70H123N19O18

Absent amino acids  CDEFMNPQRSWY

Theoretical pI  8.76

Acidic residues  0

Basic residues  2

Polar residues  6

Molecular weight (Average)  1518.86

Molecular weight (Monoisotopic)  1517.93

Common amino acids  G

Net charge  2

Instability index (II)  32.96

Aliphatic index  170.62

Grand average of hydropathicity (GRAVY)  1.275

Half Life 
  30 hours (mammalian reticulocytes, in vitro).
  >20 hours (yeast, in vivo).
  >10 hours (Escherichia coli, in vivo).

Extinction coefficients 
  Should not be visible by UV spectrophotometry.

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 24704757

Title  A family of antimicrobial and immunomodulatory peptides related to the frenatins from skin secretions of the Orinoco lime frog Sphaenorhynchus lacteus (Hylidae)

Doi 10.1016/j.peptides.2014.03.020

Year  2014

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DBAASP ID  DBAASPR_5369

DCTPep is developed by Dr.Zheng's team.