Peptide Libraray

Frenatin 2.3S

General Information

DCTPep ID DCTPep02616

Peptide Name Frenatin 2.3S

Sequence GLVGTLLGHIGKAILG

Sequence Length 16

UniProt ID Not available

PubChem CID Not available

Origin Sphaenorhynchus lacteus

Type Native peptide

Classification

Immune system stimulating peptides

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
A549	Lung adenocarcinoma	LC50>100 μM	CellTiter-Glo Luminescent Cell Viability assay	24 h	1

Hemolytic Activity Human erythrocytes: HC50=404 ± 11 µM

Normal (non-cancerous) Cytotoxicity Not available

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure DCTPep02616

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Chiral L

Physicochemical Information

Formula C70H123N19O18

Absent amino acids CDEFMNPQRSWY

Theoretical pI 8.76

Acidic residues 0

Basic residues 2

Polar residues 6

Molecular weight (Average) 1518.86

Molecular weight (Monoisotopic) 1517.93

Common amino acids G

Net charge 2

Instability index (II) 32.96

Aliphatic index 170.62

Grand average of hydropathicity (GRAVY) 1.275

Half Life
30 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).

Extinction coefficients
Should not be visible by UV spectrophotometry.

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 24704757

Title A family of antimicrobial and immunomodulatory peptides related to the frenatins from skin secretions of the Orinoco lime frog Sphaenorhynchus lacteus (Hylidae)

Doi 10.1016/j.peptides.2014.03.020

Year 2014

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available

External Code

DBAASP ID DBAASPR_5371