This work is licensed under a Creative Commons Attribution 4.0 International License.
Gageostatin B
General Information
DCTPep ID DCTPep02621
Peptide Name Gageostatin B
Sequence ELLVDLL
Sequence Length 7
UniProt ID Not available
PubChem CID 139587549
Origin Bacillus subtilis
Type Native peptide
Classification
ACP Tumor active peptide Lipopeptides
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| NCI-H23 | Lung adenocarcinoma | IC50=11.7 µg/mL | SBR assay | 48 h | 1 |
| NUGC-3 | Gastric adenocarcinoma | IC50=13.9 µg/mL | SBR assay | 48 h | 1 |
| MDA-MB-231 | Breast adenocarcinoma | IC50=16.1 µg/mL | SBR assay | 48 h | 1 |
| HCT 15 | Colon adenocarcinoma | IC50=18.3 µg/mL | SBR assay | 48 h | 1 |
| ACHN | Papillary renal cell carcinoma | IC50=18.4 µg/mL | SBR assay | 48 h | 1 |
| PC-3 | Prostate carcinoma | IC50=19.4 µg/mL | SBR assay | 48 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification 3-β-hydroxy-9,11-dimethyltridecanoic acids
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula Not Applicable
Absent amino acids Not Applicable
Theoretical pI Not Applicable
Acidic residues Not Applicable
Basic residues Not Applicable
Polar residues Not Applicable
Molecular weight (Average) 813.99
Molecular weight (Monoisotopic) 813.48
Common amino acids Not Applicable
Net charge Not Applicable
Instability index (II) Not Applicable
Aliphatic index Not Applicable
Grand average of hydropathicity (GRAVY) Not Applicable
Half Life
Not Applicable
Extinction coefficients
Not Applicable
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 24492520
Title Gageostatins A-C, antimicrobial linear lipopeptides from a marine Bacillus subtilis
Year 2014
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPN_5450
This work is licensed under a Creative Commons Attribution 4.0 International License.