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B1-C12
General Information
DCTPep ID DCTPep02629
Peptide Name B1-C12
Sequence VKRFKKFFRKLKKSV
Sequence Length 15
UniProt ID B6D434
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
ACP Tumor active peptide Lipopeptides Membrane lysis Induce apoptosis
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| K562/ADM | Blast phase chronic myelogenous leukemia, BCR-ABL12 positive; Chronic myeloid leukemia | IC50=10.0 ± 0.8 µM | MTT assay | 48 h | 1 |
| K562 | Blast phase chronic myelogenous leukemia, BCR-ABL2 positive; Chronic myeloid leukemia | IC50=11.5 ± 0.9 µM | MTT assay | 48 h | 1 |
| MCF-7 | Invasive breast carcinoma of no special type | IC50=8.8 ± 0.5 µM | MTT assay | 48 h | 1 |
| MCF-7/Taxol | Invasive breast carcinoma of no special type | IC50=9.5 ± 1.1 µM | MTT assay | 48 h | 1 |
Hemolytic Activity Human erythrocytes: <20% Hemolysis =160 µM
Normal (non-cancerous) Cytotoxicity GES-1: IC50=77.6 ± 7.3 µM; HEK293: IC50=75.8 ± 6.6 µM
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure DCTPep02629
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification CH3(CH2)10CO, Dodecanoic acid
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula Not Applicable
Absent amino acids Not Applicable
Theoretical pI Not Applicable
Acidic residues Not Applicable
Basic residues Not Applicable
Polar residues Not Applicable
Molecular weight (Average) 1939.47
Molecular weight (Monoisotopic) 1938.24
Common amino acids Not Applicable
Net charge Not Applicable
Instability index (II) Not Applicable
Aliphatic index Not Applicable
Grand average of hydropathicity (GRAVY) Not Applicable
Half Life
Not Applicable
Extinction coefficients
Not Applicable
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 26083110
Title Aliphatic acid-conjugated antimicrobial peptides--potential agents with anti-tumor, multidrug resistance-reversing activity and enhanced stability
Year 2015
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.