B1-C12

General Information


DCTPep ID  DCTPep02629

Peptide Name   B1-C12

Sequence  VKRFKKFFRKLKKSV

Sequence Length  15

UniProt ID  B6D434 

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

ACP Tumor active peptide Lipopeptides Membrane lysis Induce apoptosis



Activity Information


Cell Line Disease Activity Assay Testing Time Literature
K562/ADM Blast phase chronic myelogenous leukemia, BCR-ABL12 positive; Chronic myeloid leukemia IC50=10.0 ± 0.8 µM MTT assay 48 h 1
K562 Blast phase chronic myelogenous leukemia, BCR-ABL2 positive; Chronic myeloid leukemia IC50=11.5 ± 0.9 µM MTT assay 48 h 1
MCF-7 Invasive breast carcinoma of no special type IC50=8.8 ± 0.5 µM MTT assay 48 h 1
MCF-7/Taxol Invasive breast carcinoma of no special type IC50=9.5 ± 1.1 µM MTT assay 48 h 1

Hemolytic Activity  Human erythrocytes: <20% Hemolysis =160 µM

Normal (non-cancerous) Cytotoxicity  GES-1: IC50=77.6 ± 7.3 µM; HEK293: IC50=75.8 ± 6.6 µM

Target  Not available

Affinity  Not available

Mechanism  Not available



Structure Information


PDB ID  Not available

Predicted Structure  DCTPep02629

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  CH3(CH2)10CO, Dodecanoic acid

C-terminal Modification  Amidation

Other Modification  None

Chiral  L



Physicochemical Information


Formula  Not Applicable

Absent amino acids  Not Applicable

Theoretical pI  Not Applicable

Acidic residues  Not Applicable

Basic residues  Not Applicable

Polar residues  Not Applicable

Molecular weight (Average)  1939.47

Molecular weight (Monoisotopic)  1938.24

Common amino acids  Not Applicable

Net charge  Not Applicable

Instability index (II)  Not Applicable

Aliphatic index  Not Applicable

Grand average of hydropathicity (GRAVY)  Not Applicable

Half Life 
  Not Applicable

Extinction coefficients 
  Not Applicable

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 26083110

Title  Aliphatic acid-conjugated antimicrobial peptides--potential agents with anti-tumor, multidrug resistance-reversing activity and enhanced stability

Doi 10.1039/c5ob00752f

Year  2015

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DCTPep is developed by Dr.Zheng's team.