Peptide Libraray

Mastoparan

General Information

DCTPep ID DCTPep02655

Peptide Name Mastoparan

Sequence INLKALAALAKKIL

Sequence Length 14

UniProt ID P01514

PubChem CID 6324633

Origin Vespula lewisii

Type Native peptide

Classification

ACP Tumor active peptide Cell-penetrating peptides Induce apoptosis

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
U-373MG	Astrocytoma	LD50=28.67 μM	MTT assay	4 h	1

Hemolytic Activity Not available

Normal (non-cancerous) Cytotoxicity Not available

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID 1D7N

Predicted Structure DCTPep02655

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Amidation

Other Modification None

Chiral L

Physicochemical Information

Formula C70H130N18O16

Absent amino acids CDEFGHMPQRSTVWY

Theoretical pI 10.30

Acidic residues 0

Basic residues 3

Polar residues 1

Molecular weight (Average) 1479.91

Molecular weight (Monoisotopic) 1478.99

Common amino acids AL

Net charge 3

Instability index (II) 10.91

Aliphatic index 195.71

Grand average of hydropathicity (GRAVY) 1.157

Half Life
20 hours (mammalian reticulocytes, in vitro).
30 min (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).

Extinction coefficients
Should not be visible by UV spectrophotometry.

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 22148546

Title Enantiomer-specific bioactivities of peptidomimetic analogues of mastoparan and mitoparan: characterization of inverso mastoparan as a highly efficient cell penetrating peptide

Doi 10.1021/bc2002924

Year 2012

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available