This work is licensed under a Creative Commons Attribution 4.0 International License.
Apidaecin-1B [R4K, I8R]
General Information
DCTPep ID DCTPep02686
Peptide Name Apidaecin-1B [R4K, I8R]
Sequence GNNKPVYRPQPRPPHPRL
Sequence Length 18
UniProt ID P35581
PubChem CID 102602729
Origin Synthetic
Type Synthetic peptide
Classification
ACP Tumor active peptide
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| A431 | Skin squamous cell carcinoma | 30% Cytotoxicity=10 µM | MTT assay | 24 h | 1 |
| MDA-MB-231 | Breast adenocarcinoma | Not active up to 10 µM | MTT assay | 24 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure DCTPep02686
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C95H151N33O23
Absent amino acids ACDEFIMSTW
Theoretical pI 11.72
Acidic residues 0
Basic residues 5
Polar residues 4
Molecular weight (Average) 2123.45
Molecular weight (Monoisotopic) 2122.17
Common amino acids P
Net charge 5
Instability index (II) 54.33
Aliphatic index 37.78
Grand average of hydropathicity (GRAVY) -1.911
Half Life
30 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 1490
Abs 0.1% (=1 g/l) 0.702
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 31209863
Title Identification and elucidation of proline-rich antimicrobial peptides with enhanced potency and delivery
Year 2019
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_13541
This work is licensed under a Creative Commons Attribution 4.0 International License.