Pyrrhocoricin

General Information


DCTPep ID  DCTPep02687

Peptide Name   Pyrrhocoricin

Sequence  VDKGSYLPRPTPPRPIYNRN

Sequence Length  20

UniProt ID  P37362 

PubChem CID  Not available

Origin  Pyrrhocoris apterus

Type  Native peptide

Classification

  

Cancer therapy related peptides



Activity Information


Cell Line Disease Activity Assay Testing Time Literature
A431 Skin squamous cell carcinoma <10% Cytotoxicity=10 µM MTT assay 24 h 1
MDA-MB-231 Breast adenocarcinoma Not active up to 10 µM MTT assay 24 h 1

Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available



Structure Information


PDB ID  Not available

Predicted Structure  DCTPep02687

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C105H166N32O29

Absent amino acids  ACEFHMQW

Theoretical pI  10.27

Acidic residues  1

Basic residues  4

Polar residues  7

Molecular weight (Average)  2340.67

Molecular weight (Monoisotopic)  2339.25

Common amino acids  P

Net charge  3

Instability index (II)  30.65

Aliphatic index  53.50

Grand average of hydropathicity (GRAVY)  -1.395

Half Life 
  100 hours (mammalian reticulocytes, in vitro).
  >20 hours (yeast, in vivo).
  >10 hours (Escherichia coli, in vivo).

Extinction coefficients 
  Ext. coefficient 2980
  Abs 0.1% (=1 g/l) 1.273

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 31209863

Title  Identification and elucidation of proline-rich antimicrobial peptides with enhanced potency and delivery

Doi 10.1002/bit.27092

Year  2019

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DBAASP ID  DBAASPR_13548

DCTPep is developed by Dr.Zheng's team.