Peptide Libraray

Pyrrhocoricin

General Information

DCTPep ID DCTPep02687

Peptide Name Pyrrhocoricin

Sequence VDKGSYLPRPTPPRPIYNRN

Sequence Length 20

UniProt ID P37362

PubChem CID Not available

Origin Pyrrhocoris apterus

Type Native peptide

Classification

Cancer therapy related peptides

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
A431	Skin squamous cell carcinoma	<10% Cytotoxicity=10 µM	MTT assay	24 h	1
MDA-MB-231	Breast adenocarcinoma	Not active up to 10 µM	MTT assay	24 h	1

Hemolytic Activity Not available

Normal (non-cancerous) Cytotoxicity Not available

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure DCTPep02687

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Chiral L

Physicochemical Information

Formula C105H166N32O29

Absent amino acids ACEFHMQW

Theoretical pI 10.27

Acidic residues 1

Basic residues 4

Polar residues 7

Molecular weight (Average) 2340.67

Molecular weight (Monoisotopic) 2339.25

Common amino acids P

Net charge 3

Instability index (II) 30.65

Aliphatic index 53.50

Grand average of hydropathicity (GRAVY) -1.395

Half Life
100 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).

Extinction coefficients
Ext. coefficient 2980
Abs 0.1% (=1 g/l) 1.273

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 31209863

Title Identification and elucidation of proline-rich antimicrobial peptides with enhanced potency and delivery

Doi 10.1002/bit.27092

Year 2019

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available

External Code

DBAASP ID DBAASPR_13548