This work is licensed under a Creative Commons Attribution 4.0 International License.
Pyrrhocoricin [L7R, R14K]
General Information
DCTPep ID DCTPep02688
Peptide Name Pyrrhocoricin [L7R, R14K]
Sequence VDKGSYRPRPTPPKPIYNRN
Sequence Length 20
UniProt ID P37362
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Cancer therapy related peptides
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| A431 | Skin squamous cell carcinoma | <10% Cytotoxicity=10 µM | MTT assay | 24 h | 1 |
| MDA-MB-231 | Breast adenocarcinoma | Not active up to 10 µM | MTT assay | 24 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure DCTPep02688
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C105H167N33O29
Absent amino acids ACEFHLMQW
Theoretical pI 10.43
Acidic residues 1
Basic residues 5
Polar residues 7
Molecular weight (Average) 2355.68
Molecular weight (Monoisotopic) 2354.26
Common amino acids P
Net charge 4
Instability index (II) 12.56
Aliphatic index 34.00
Grand average of hydropathicity (GRAVY) -1.780
Half Life
100 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 2980
Abs 0.1% (=1 g/l) 1.265
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 31209863
Title Identification and elucidation of proline-rich antimicrobial peptides with enhanced potency and delivery
Year 2019
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_13550
This work is licensed under a Creative Commons Attribution 4.0 International License.