This work is licensed under a Creative Commons Attribution 4.0 International License.
C14C3lexin, Ranalexin (7-20) C14
General Information
DCTPep ID DCTPep02725
Peptide Name C14C3lexin, Ranalexin (7-20) C14
Sequence KIVPAMICAVTKKC
Sequence Length 14
UniProt ID P39084
PubChem CID Not available
Origin Synthetic (Derived from Ranalexin)
Type Synthetic peptide
Classification
ACP Tumor active peptide Lipopeptides Membrane-targeted
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| MEC-7 | Invasive breast carcinoma of no special type | IC50=12 µg/ml | MTT assay | 24 h | 1 |
| LNCaP C4-2 | Prostate carcinoma | IC50=16 µg/ml | MTT assay | 24 h | 1 |
| HepG2 | Hepatoblastoma | IC50=18 µg/ml | MTT assay | 24 h | 1 |
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | IC50=30 µg/ml | MTT assay | 24 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity CHO-K1: IC50=17 µg/ml; PBMC: IC50=15 µg/ml
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure DCTPep02725
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond Cys8<--->Cys14
N-terminal Modification CH3(CH2)12CO, Myristic acid
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula Not Applicable
Absent amino acids Not Applicable
Theoretical pI Not Applicable
Acidic residues Not Applicable
Basic residues Not Applicable
Polar residues Not Applicable
Molecular weight (Average) 1504.97
Molecular weight (Monoisotopic) 1503.83
Common amino acids Not Applicable
Net charge Not Applicable
Instability index (II) Not Applicable
Aliphatic index Not Applicable
Grand average of hydropathicity (GRAVY) Not Applicable
Half Life
Not Applicable
Extinction coefficients
Not Applicable
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 29649587
Title A novel tool against multiresistant bacterial pathogens: lipopeptide modification of the natural antimicrobial peptide ranalexin for enhanced antimicrobial activity and improved pharmacokinetics
Doi 10.1016/j.ijantimicag.2018.03.023
Year 2018
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_13798
This work is licensed under a Creative Commons Attribution 4.0 International License.