C10C3lexin, Ranalexin (7-20) C10

General Information


DCTPep ID  DCTPep02729

Peptide Name   C10C3lexin, Ranalexin (7-20) C10

Sequence  KIVPAMICAVTKKC

Sequence Length  14

UniProt ID  P39084 

PubChem CID  Not available

Origin  Synthetic (Derived from Ranalexin)

Type  Synthetic peptide

Classification

  

ACP Tumor active peptide Lipopeptides Membrane-targeted



Activity Information


Cell Line Disease Activity Assay Testing Time Literature
LNCaP C4-2 Prostate carcinoma IC50=35 µg/ml MTT assay 24 h 1
MEC-7 Invasive breast carcinoma of no special type IC50=35 µg/ml MTT assay 24 h 1
HeLa Human papillomavirus-related endocervical adenocarcinoma IC50=36 µg/ml MTT assay 24 h 1
HepG2 Hepatoblastoma IC50=48 µg/ml MTT assay 24 h 1

Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  CHO-K1: IC50=40 µg/ml; PBMC: IC50=108.1 µg/ml

Target  Not available

Affinity  Not available

Mechanism  Not available



Structure Information


PDB ID  Not available

Predicted Structure  DCTPep02729

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Cyclic

Disulfide/Other Bond  Cys8<--->Cys14

N-terminal Modification  CH3(CH2)8CO, Decanoic acid

C-terminal Modification  Free

Other Modification  None

Chiral  L



Physicochemical Information


Formula  Not Applicable

Absent amino acids  Not Applicable

Theoretical pI  Not Applicable

Acidic residues  Not Applicable

Basic residues  Not Applicable

Polar residues  Not Applicable

Molecular weight (Average)  1504.97

Molecular weight (Monoisotopic)  1503.83

Common amino acids  Not Applicable

Net charge  Not Applicable

Instability index (II)  Not Applicable

Aliphatic index  Not Applicable

Grand average of hydropathicity (GRAVY)  Not Applicable

Half Life 
  Not Applicable

Extinction coefficients 
  Not Applicable

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 29649587

Title  A novel tool against multiresistant bacterial pathogens: lipopeptide modification of the natural antimicrobial peptide ranalexin for enhanced antimicrobial activity and improved pharmacokinetics

Doi 10.1016/j.ijantimicag.2018.03.023

Year  2018

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DBAASP ID  DBAASPS_13802

DCTPep is developed by Dr.Zheng's team.