This work is licensed under a Creative Commons Attribution 4.0 International License.
G(LLKK)3L-NH2
General Information
DCTPep ID DCTPep02730
Peptide Name G(LLKK)3L-NH2
Sequence GLLKKLLKKLLKKL
Sequence Length 14
UniProt ID Not available
PubChem CID 71596801
Origin Synthetic
Type Synthetic peptide
Classification
ACP Tumor active peptide Membrane-targeted
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| HL-60 | Adult acute myeloid leukemia; Acute myeloid leukemia | >80% Killing=50 µM | MTT assay | 24 h | 1 |
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | 70% Killing=50 µM | MTT assay | 24 h | 1 |
Hemolytic Activity Human erythrocytes: HC50=30 µM
Normal (non-cancerous) Cytotoxicity Human keratinocytes HaCat: >90% Killing=40 µM
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure DCTPep02730
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C80H154N20O15
Absent amino acids ACDEFHIMNPQRSTVWY
Theoretical pI 10.70
Acidic residues 0
Basic residues 6
Polar residues 1
Molecular weight (Average) 1636.23
Molecular weight (Monoisotopic) 1635.19
Common amino acids L
Net charge 6
Instability index (II) -27.1
Aliphatic index 195.00
Grand average of hydropathicity (GRAVY) 0.200
Half Life
30 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).
Extinction coefficients
Should not be visible by UV spectrophotometry.
Amino acid distribution
Literature Information
Literature 1
Pubmed ID Not available
Title Amino acid side chains affect the bioactivity of designed short peptide amphiphiles
Year 2016
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_13973
This work is licensed under a Creative Commons Attribution 4.0 International License.