Helical3

General Information


DCTPep ID  DCTPep02760

Peptide Name   Helical3

Sequence  GLLDIAGGNAETLAGHAV

Sequence Length  18

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

Membrane-targeted



Activity Information


Cell Line Disease Activity Assay Testing Time Literature
A549 Lung adenocarcinoma EC50>50 µM MTT assay 24 h 1
MCF-7 Invasive breast carcinoma of no special type EC50>50 µM MTT assay 24 h 1

Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available



Structure Information


PDB ID  Not available

Predicted Structure  DCTPep02760

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Amidation

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C72H119N21O25

Absent amino acids  CFKMPQRSWY

Theoretical pI  4.35

Acidic residues  2

Basic residues  1

Polar residues  6

Molecular weight (Average)  1678.86

Molecular weight (Monoisotopic)  1677.87

Common amino acids  AG

Net charge  -1

Instability index (II)  11.58

Aliphatic index  125.00

Grand average of hydropathicity (GRAVY)  0.628

Half Life 
  30 hours (mammalian reticulocytes, in vitro).
  >20 hours (yeast, in vivo).
  >10 hours (Escherichia coli, in vivo).

Extinction coefficients 
  Should not be visible by UV spectrophotometry.

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 31375699

Title  In silico design and optimization of selective membranolytic anticancer peptides

Doi 10.1038/s41598-019-47568-9

Year  2019

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DCTPep is developed by Dr.Zheng's team.