AmphiArc2 Off2.9
General Information
DCTPep ID DCTPep02788
Peptide Name AmphiArc2 Off2.9
Sequence HLIHRLHTYWHKPWHYLGKL
Sequence Length 20
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Membrane-targeted
Activity Information
Cell Line | Disease | Activity | Assay | Testing Time | Literature |
---|---|---|---|---|---|
A549 | Lung adenocarcinoma | EC50>100 µM | MTT assay | 24 h | 1 |
MCF-7 | Invasive breast carcinoma of no special type | EC50>100 µM | MTT assay | 24 h | 1 |
Hemolytic Activity Human erythrocytes: HC50>200 µM
Normal (non-cancerous) Cytotoxicity HDMEC: EC50=135 ± 2 µM
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure DCTPep02788
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C129H183N37O24
Absent amino acids ACDEFMNQSV
Theoretical pI 10.00
Acidic residues 0
Basic residues 8
Polar residues 4
Molecular weight (Average) 2636.11
Molecular weight (Monoisotopic) 2634.42
Common amino acids H
Net charge 8
Instability index (II) 50.51
Aliphatic index 97.50
Grand average of hydropathicity (GRAVY) -0.785
Half Life
3.5 hours (mammalian reticulocytes, in vitro).
10 min (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 13980
Abs 0.1% (=1 g/l) 5.303
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 31375699
Title In silico design and optimization of selective membranolytic anticancer peptides
Doi 10.1038/s41598-019-47568-9
Year 2019
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_16613