This work is licensed under a Creative Commons Attribution 4.0 International License.
ChBac3.4-1-NH2
General Information
DCTPep ID DCTPep02803
Peptide Name ChBac3.4-1-NH2
Sequence RFRLPFRRIHPPPFVRIHPPPFYRRFL
Sequence Length 27
UniProt ID P85170
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
ACP Tumor active peptide Induce apoptosis
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| U-937 | Adult acute monocytic leukemi; Acute monoblastic/monocytic leukemia | IC50=4.5 ± 1.6 μM | MTT assay | overnight | 1 |
| K562 | Blast phase chronic myelogenous leukemia, BCR-ABL1 positive; Chronic myeloid leukemia | IC50=8.4 ± 1.1 μM | MTT assay | overnight | 1 |
Hemolytic Activity Human erythrocytes: <5% Hemolysis=64 µM
Normal (non-cancerous) Cytotoxicity Human PBMC: IC50=12.1 ± 0.8 µM
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure DCTPep02803
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C172H256N52O29
Absent amino acids ACDEGKMNQSTW
Theoretical pI 12.40
Acidic residues 0
Basic residues 9
Polar residues 1
Molecular weight (Average) 3516.26
Molecular weight (Monoisotopic) 3514.02
Common amino acids PR
Net charge 9
Instability index (II) 121.94
Aliphatic index 68.52
Grand average of hydropathicity (GRAVY) -0.578
Half Life
1 hours (mammalian reticulocytes, in vitro).
2 min (yeast, in vivo).
2 min (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 1490
Abs 0.1% (=1 g/l) 0.424
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 33194795
Title Caprine Bactenecins as Promising Tools for Developing New Antimicrobial and Antitumor Drugs
Year 2020
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_16645
This work is licensed under a Creative Commons Attribution 4.0 International License.