This work is licensed under a Creative Commons Attribution 4.0 International License.
RFR-ChBac3.4-1-NH2
General Information
DCTPep ID DCTPep02805
Peptide Name RFR-ChBac3.4-1-NH2
Sequence RFRRFRLPFRRIHPPPFVRIHPPPFYRRFL
Sequence Length 30
UniProt ID P85170
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
ACP Tumor active peptide Induce apoptosis
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| K562 | Blast phase chronic myelogenous leukemia, BCR-ABL1 positive; Chronic myeloid leukemia | IC50=20.0 ± 3.4 μM | MTT assay | overnight | 1 |
| U-937 | Adult acute monocytic leukemi; Acute monoblastic/monocytic leukemia | IC50=3.2 ± 0.4 μM | MTT assay | overnight | 1 |
Hemolytic Activity Human erythrocytes: <5% Hemolysis=64 µM
Normal (non-cancerous) Cytotoxicity Human PBMC: IC50=18.3 ± 4.1 µM
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure DCTPep02805
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C193H289N61O32
Absent amino acids ACDEGKMNQSTW
Theoretical pI 12.54
Acidic residues 0
Basic residues 11
Polar residues 1
Molecular weight (Average) 3975.81
Molecular weight (Monoisotopic) 3973.29
Common amino acids R
Net charge 11
Instability index (II) 129.84
Aliphatic index 61.67
Grand average of hydropathicity (GRAVY) -0.727
Half Life
1 hours (mammalian reticulocytes, in vitro).
2 min (yeast, in vivo).
2 min (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 1490
Abs 0.1% (=1 g/l) 0.375
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 33194795
Title Caprine Bactenecins as Promising Tools for Developing New Antimicrobial and Antitumor Drugs
Year 2020
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_16647
This work is licensed under a Creative Commons Attribution 4.0 International License.