Peptide Libraray

Modifed Coco1

General Information

DCTPep ID DCTPep02812

Peptide Name Modifed Coco1

Sequence FTILKKLKSFIK

Sequence Length 12

UniProt ID I0YNC0

PubChem CID Not available

Origin Synthetic

Type Synthetic peptide

Classification

Membrane-targeted

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
A549	Lung adenocarcinoma	CC50>200 μM	MTT assay	24 h	1

Hemolytic Activity Human erythrocytes: <10% Hemolysis=50 µM

Normal (non-cancerous) Cytotoxicity Not available

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Chiral L

Physicochemical Information

Formula C73H124N16O15

Absent amino acids ACDEGHMNPQRVWY

Theoretical pI 10.48

Acidic residues 0

Basic residues 4

Polar residues 2

Molecular weight (Average) 1465.89

Molecular weight (Monoisotopic) 1464.94

Common amino acids K

Net charge 4

Instability index (II) -3.08

Aliphatic index 130.00

Grand average of hydropathicity (GRAVY) 0.425

Half Life
1.1 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
2 min (Escherichia coli, in vivo).

Extinction coefficients
Should not be visible by UV spectrophotometry.

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 33063186

Title Design of antimicrobial and cytolytic peptides by computational analysis of bacterial, algal, and invertebrate proteomes

Doi 10.1007/s00726-020-02900-w

Year 2020

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available

External Code

DBAASP ID DBAASPS_16906