Peptide Libraray

Modifed Coco2

General Information

DCTPep ID DCTPep02813

Peptide Name Modifed Coco2

Sequence KLVKKLLKKYITF

Sequence Length 13

UniProt ID I0Z3W2

PubChem CID Not available

Origin Synthetic

Type Synthetic peptide

Classification

ACP Tumor active peptide Membrane-targeted

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
A549	Lung adenocarcinoma	CC50=200 μM	MTT assay	24 h	1

Hemolytic Activity Human erythrocytes: <10% Hemolysis=50 µM

Normal (non-cancerous) Cytotoxicity Not available

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure DCTPep02813

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Chiral L

Physicochemical Information

Formula C81H140N18O16

Absent amino acids ACDEGHMNPQRSW

Theoretical pI 10.30

Acidic residues 0

Basic residues 5

Polar residues 2

Molecular weight (Average) 1622.11

Molecular weight (Monoisotopic) 1621.07

Common amino acids K

Net charge 5

Instability index (II) -3.08

Aliphatic index 142.31

Grand average of hydropathicity (GRAVY) 0.108

Half Life
1.3 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
3 min (Escherichia coli, in vivo).

Extinction coefficients
Ext. coefficient 1490
Abs 0.1% (=1 g/l) 0.919

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 33063186

Title Design of antimicrobial and cytolytic peptides by computational analysis of bacterial, algal, and invertebrate proteomes

Doi 10.1007/s00726-020-02900-w

Year 2020

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available

External Code

DBAASP ID DBAASPS_16907