Peptide Libraray

Modifed Coco3

General Information

DCTPep ID DCTPep02814

Peptide Name Modifed Coco3

Sequence LARFVLRILKYGFK

Sequence Length 14

UniProt ID I0YQ90

PubChem CID Not available

Origin Synthetic

Type Synthetic peptide

Classification

ACP Tumor active peptide Membrane-targeted

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
A549	Lung adenocarcinoma	CC50=12.5 μM	MTT assay	24 h	1
CaCo-2	Colon adenocarcinoma	CC50=25 μM	MTT assay	24 h	1

Hemolytic Activity Human erythrocytes: 10% Hemolysis=9.38 µM

Normal (non-cancerous) Cytotoxicity Not available

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure DCTPep02814

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Chiral L

Physicochemical Information

Formula C85H138N22O16

Absent amino acids CDEHMNPQSTW

Theoretical pI 11.10

Acidic residues 0

Basic residues 4

Polar residues 2

Molecular weight (Average) 1724.17

Molecular weight (Monoisotopic) 1723.07

Common amino acids L

Net charge 4

Instability index (II) 13.94

Aliphatic index 139.29

Grand average of hydropathicity (GRAVY) 0.643

Half Life
5.5 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
2 min (Escherichia coli, in vivo).

Extinction coefficients
Ext. coefficient 1490
Abs 0.1% (=1 g/l) 0.864

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 33063186

Title Design of antimicrobial and cytolytic peptides by computational analysis of bacterial, algal, and invertebrate proteomes

Doi 10.1007/s00726-020-02900-w

Year 2020

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available

External Code

DBAASP ID DBAASPS_16908