Peptide Libraray

Modifed Opero2

General Information

DCTPep ID DCTPep02816

Peptide Name Modifed Opero2

Sequence GLKKVIKLLRPLL

Sequence Length 13

UniProt ID A0A0L7L9V8

PubChem CID Not available

Origin Synthetic

Type Synthetic peptide

Classification

ACP Tumor active peptide Membrane-targeted

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
A549	Lung adenocarcinoma	CC50=50 μM	MTT assay	24 h	1

Hemolytic Activity Human erythrocytes: <10% Hemolysis=50 µM

Normal (non-cancerous) Cytotoxicity Not available

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure DCTPep02816

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Chiral L

Physicochemical Information

Formula C72H135N19O14

Absent amino acids ACDEFHMNQSTWY

Theoretical pI 11.26

Acidic residues 0

Basic residues 4

Polar residues 1

Molecular weight (Average) 1490.98

Molecular weight (Monoisotopic) 1490.04

Common amino acids L

Net charge 4

Instability index (II) 12.74

Aliphatic index 202.31

Grand average of hydropathicity (GRAVY) 0.731

Half Life
30 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).

Extinction coefficients
Should not be visible by UV spectrophotometry.

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 33063186

Title Design of antimicrobial and cytolytic peptides by computational analysis of bacterial, algal, and invertebrate proteomes

Doi 10.1007/s00726-020-02900-w

Year 2020

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available

External Code

DBAASP ID DBAASPS_16910