Modifed Opero3

General Information


DCTPep ID  DCTPep02817

Peptide Name   Modifed Opero3

Sequence  ILKPKLWKLTVVARKIIK

Sequence Length  18

UniProt ID  A0A0L7LPN7 

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

ACP Tumor active peptide Membrane-targeted



Activity Information


Cell Line Disease Activity Assay Testing Time Literature
A549 Lung adenocarcinoma CC50=200 μM MTT assay 24 h 1

Hemolytic Activity  Human erythrocytes: <10% Hemolysis=50 µM

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available



Structure Information


PDB ID  Not available

Predicted Structure  DCTPep02817

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C105H187N27O20

Absent amino acids  CDEFGHMNQSY

Theoretical pI  11.39

Acidic residues  0

Basic residues  6

Polar residues  1

Molecular weight (Average)  2147.81

Molecular weight (Monoisotopic)  2146.44

Common amino acids  K

Net charge  6

Instability index (II)  5.53

Aliphatic index  167.78

Grand average of hydropathicity (GRAVY)  0.439

Half Life 
  20 hours (mammalian reticulocytes, in vitro).
  30 min (yeast, in vivo).
  >10 hours (Escherichia coli, in vivo).

Extinction coefficients 
  Ext. coefficient 5500
  Abs 0.1% (=1 g/l) 2.561

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 33063186

Title  Design of antimicrobial and cytolytic peptides by computational analysis of bacterial, algal, and invertebrate proteomes

Doi 10.1007/s00726-020-02900-w

Year  2020

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DBAASP ID  DBAASPS_16911

DCTPep is developed by Dr.Zheng's team.