Modifed Pyro1
General Information
DCTPep ID DCTPep02818
Peptide Name Modifed Pyro1
Sequence IVIKSLGKFLKNVGGFAG
Sequence Length 18
UniProt ID O58222
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Membrane-targeted
Activity Information
Cell Line | Disease | Activity | Assay | Testing Time | Literature |
---|---|---|---|---|---|
A549 | Lung adenocarcinoma | CC50>200 μM | MTT assay | 24 h | 1 |
Hemolytic Activity Human erythrocytes: <10% Hemolysis=50 µM
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure DCTPep02818
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C88H146N22O21
Absent amino acids CDEHMPQRTWY
Theoretical pI 10.30
Acidic residues 0
Basic residues 3
Polar residues 6
Molecular weight (Average) 1848.26
Molecular weight (Monoisotopic) 1847.1
Common amino acids G
Net charge 3
Instability index (II) -7.28
Aliphatic index 124.44
Grand average of hydropathicity (GRAVY) 0.822
Half Life
20 hours (mammalian reticulocytes, in vitro).
30 min (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).
Extinction coefficients
Should not be visible by UV spectrophotometry.
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 33063186
Title Design of antimicrobial and cytolytic peptides by computational analysis of bacterial, algal, and invertebrate proteomes
Doi 10.1007/s00726-020-02900-w
Year 2020
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_16912