Peptide Libraray

Modifed Thermo1

General Information

DCTPep ID DCTPep02820

Peptide Name Modifed Thermo1

Sequence ITKWLLNAIKKGFKL

Sequence Length 15

UniProt ID B6YW36

PubChem CID Not available

Origin Synthetic

Type Synthetic peptide

Classification

Membrane-targeted

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
A549	Lung adenocarcinoma	CC50>200 μM	MTT assay	24 h	1

Hemolytic Activity Human erythrocytes: 10% Hemolysis=21.9 µM

Normal (non-cancerous) Cytotoxicity Not available

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure DCTPep02820

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Chiral L

Physicochemical Information

Formula C87H145N21O18

Absent amino acids CDEHMPQRSVY

Theoretical pI 10.48

Acidic residues 0

Basic residues 4

Polar residues 3

Molecular weight (Average) 1773.24

Molecular weight (Monoisotopic) 1772.11

Common amino acids K

Net charge 4

Instability index (II) -9.44

Aliphatic index 136.67

Grand average of hydropathicity (GRAVY) 0.260

Half Life
20 hours (mammalian reticulocytes, in vitro).
30 min (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).

Extinction coefficients
Ext. coefficient 5500
Abs 0.1% (=1 g/l) 3.102

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 33063186

Title Design of antimicrobial and cytolytic peptides by computational analysis of bacterial, algal, and invertebrate proteomes

Doi 10.1007/s00726-020-02900-w

Year 2020

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available

External Code

DBAASP ID DBAASPS_16914