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LHH1
General Information
DCTPep ID DCTPep02842
Peptide Name LHH1
Sequence AFALIAGALYRIFHRR
Sequence Length 16
UniProt ID Q036I7
PubChem CID Not available
Origin Lactobacillus casei HZ1
Type Synthetic peptide
Classification
ACP Tumor active peptide Membrane lysis Induce apoptosis
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| C666-1 | Nasopharyngeal carcinoma | IC50=18.27 μM | MTT assay | 24 h | 1 |
| MGC-803 | Gastric mucinous adenocarcinoma | IC50=31.55 μM | MTT assay | 24 h | 1 |
| HCT 116 | Colon carcinoma | IC50=40.83 μM | MTT assay | 24 h | 1 |
Hemolytic Activity Goat erythrocytes: HC50=187.2 µM
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure DCTPep02842
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C89H139N27O18
Absent amino acids CDEKMNPQSTVW
Theoretical pI 11.71
Acidic residues 0
Basic residues 4
Polar residues 2
Molecular weight (Average) 1875.25
Molecular weight (Monoisotopic) 1874.08
Common amino acids A
Net charge 4
Instability index (II) 29.3
Aliphatic index 122.50
Grand average of hydropathicity (GRAVY) 0.688
Half Life
4.4 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 1490
Abs 0.1% (=1 g/l) 0.795
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 33175275
Title LHH1, a novel antimicrobial peptide with anti-cancer cell activity identified from Lactobacillus casei HZ1
Doi 10.1186/s13568-020-01139-8
Year 2020
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_16955
This work is licensed under a Creative Commons Attribution 4.0 International License.