DCTPep ID  DCTPep02848

Peptide Name   Arenicin-3 [V8,13A;Y9R], AA139

Sequence  GFCWYVCARRNGARVCYRRCN

Sequence Length  21

UniProt ID  A0A3F2YLM5 

PubChem CID  Not available

Origin  Synthetic (Derived from Arenicin-3)

Type  Synthetic peptide

Hemolytic Activity  Human erythrocytes: HC10= µg/ml

Normal (non-cancerous) Cytotoxicity  HEK-293: CC50>300 µg/ml; HK-2: CC50>250 µg/ml

Target  Not available

Affinity  Not available

Mechanism  Not available

PDB ID  5V11  

Predicted Structure  DCTPep02848

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Cyclic

Disulfide/Other Bond  Cys3<--->Cys20; Cys7<--->Cys16

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Chiral  L

Grand average of hydropathicity (GRAVY)  -0.429

Half Life 
  30 hours (mammalian reticulocytes, in vitro).
  >20 hours (yeast, in vivo).
  >10 hours (Escherichia coli, in vivo).

Extinction coefficients 
  Ext. coefficient 8730
  Abs 0.1% (=1 g/l) 3.418, assuming all pairs of Cys residues form cystines
  Ext. coefficient 8480
  Abs 0.1% (=1 g/l) 3.320, assuming all Cys residues are reduced

Amino acid distribution

Literature 1

Pubmed ID 32576824

Title  An amphipathic peptide with antibiotic activity against multidrug-resistant Gram-negative bacteria

Doi 10.1038/s41467-020-16950-x

Year  2020

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available

DBAASP ID  DBAASPS_17218