DCTPep ID  DCTPep02853

Peptide Name   Arenicin-3 [Y5N,V15I,Y17H], NZ17211

Sequence  GFCWNVCVYRNGVRICHRRCN

Sequence Length  21

UniProt ID  A0A3F2YLM5 

PubChem CID  Not available

Origin  Synthetic (Derived from Arenicin-3)

Type  Synthetic peptide

Hemolytic Activity  Human erythrocytes: HC10= µg/ml

Normal (non-cancerous) Cytotoxicity  HEK-293: CC50>300 µg/ml; HK-2: CC50>250 µg/ml

Target  Not available

Affinity  Not available

Mechanism  Not available

PDB ID  Not available

Predicted Structure  DCTPep02853

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Cyclic

Disulfide/Other Bond  Cys3<--->Cys20; Cys7<--->Cys16

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Chiral  L

Grand average of hydropathicity (GRAVY)  -0.229

Half Life 
  30 hours (mammalian reticulocytes, in vitro).
  >20 hours (yeast, in vivo).
  >10 hours (Escherichia coli, in vivo).

Extinction coefficients 
  Ext. coefficient 7240
  Abs 0.1% (=1 g/l) 2.833, assuming all pairs of Cys residues form cystines
  Ext. coefficient 6990
  Abs 0.1% (=1 g/l) 2.735, assuming all Cys residues are reduced

Amino acid distribution

Literature 1

Pubmed ID 32576824

Title  An amphipathic peptide with antibiotic activity against multidrug-resistant Gram-negative bacteria

Doi 10.1038/s41467-020-16950-x

Year  2020

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available

DBAASP ID  DBAASPS_17223