Peptide Libraray

Ixosin

General Information

DCTPep ID DCTPep02857

Peptide Name Ixosin

Sequence GLHKVMREVLGYERNSYKKFFLR

Sequence Length 23

UniProt ID Q2LKX9

PubChem CID Not available

Origin Ixodes sinensis

Type Native peptide

Classification

Cancer therapy related peptides

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
HeLa	Human papillomavirus-related endocervical adenocarcinoma	9% Killing=16-32 µM	MTT assay	24 h	1

Hemolytic Activity Not available

Normal (non-cancerous) Cytotoxicity HEK-293: Not active up to 32 µM

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure DCTPep02857

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Amidation

Other Modification None

Chiral L

Physicochemical Information

Formula C132H208N38O32S1

Absent amino acids ACDIPQTW

Theoretical pI 10.16

Acidic residues 2

Basic residues 7

Polar residues 6

Molecular weight (Average) 2871.4

Molecular weight (Monoisotopic) 2869.55

Common amino acids KLR

Net charge 5

Instability index (II) 19.66

Aliphatic index 76.09

Grand average of hydropathicity (GRAVY) -0.687

Half Life
30 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).

Extinction coefficients
Ext. coefficient 2980
Abs 0.1% (=1 g/l) 1.038

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 27622949

Title Central Role of the Copper-Binding Motif in the Complex Mechanism of Action of Ixosin: Enhancing Oxidative Damage and Promoting Synergy with Ixosin B

Doi 10.1021/acsinfecdis.5b00140

Year 2016

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available

External Code

DBAASP ID DBAASPR_17324