Peptide Libraray

Ixosin (4-18)[E8K,E13L,S16V], Ixosin-pch4–18

General Information

DCTPep ID DCTPep02862

Peptide Name Ixosin (4-18)[E8K,E13L,S16V], Ixosin-pch4–18

Sequence KVMRKVLGYLRNVYK

Sequence Length 15

UniProt ID Q2LKX9

PubChem CID Not available

Origin Synthetic

Type Synthetic peptide

Classification

Cancer therapy related peptides

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
HeLa	Human papillomavirus-related endocervical adenocarcinoma	19% Killing=2 µM	MTT assay	24 h	1

Hemolytic Activity Not available

Normal (non-cancerous) Cytotoxicity HEK-293: 15% Killing=2 µM

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure DCTPep02862

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Amidation

Other Modification None

Chiral L

Physicochemical Information

Formula C86H147N25O19S1

Absent amino acids ACDEFHIPQSTW

Theoretical pI 10.56

Acidic residues 0

Basic residues 5

Polar residues 4

Molecular weight (Average) 1867.33

Molecular weight (Monoisotopic) 1866.1

Common amino acids KV

Net charge 5

Instability index (II) 3.37

Aliphatic index 110.00

Grand average of hydropathicity (GRAVY) -0.340

Half Life
1.3 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
3 min (Escherichia coli, in vivo).

Extinction coefficients
Ext. coefficient 2980
Abs 0.1% (=1 g/l) 1.596

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 27622949

Title Central Role of the Copper-Binding Motif in the Complex Mechanism of Action of Ixosin: Enhancing Oxidative Damage and Promoting Synergy with Ixosin B

Doi 10.1021/acsinfecdis.5b00140

Year 2016

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available

External Code

DBAASP ID DBAASPR_17329