Ixosin (4-18)

General Information


DCTPep ID  DCTPep02866

Peptide Name   Ixosin (4-18)

Sequence  KVMREVLGYERNSYK

Sequence Length  15

UniProt ID  Q2LKX9 

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

Cancer therapy related peptides



Activity Information


Cell Line Disease Activity Assay Testing Time Literature
HeLa Human papillomavirus-related endocervical adenocarcinoma 3% Killing=128 µM MTT assay 24 h 1

Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  HEK-293: 14% Killing>128 µM

Target  Not available

Affinity  Not available

Mechanism  Not available



Structure Information


PDB ID  Not available

Predicted Structure  DCTPep02866

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Amidation

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C82H134N24O24S1

Absent amino acids  ACDFHIPQTW

Theoretical pI  9.52

Acidic residues  2

Basic residues  4

Polar residues  5

Molecular weight (Average)  1872.17

Molecular weight (Monoisotopic)  1870.97

Common amino acids  EKRVY

Net charge  2

Instability index (II)  -3.81

Aliphatic index  64.67

Grand average of hydropathicity (GRAVY)  -1.133

Half Life 
  1.3 hours (mammalian reticulocytes, in vitro).
  3 min (yeast, in vivo).
  3 min (Escherichia coli, in vivo).

Extinction coefficients 
  Ext. coefficient 2980
  Abs 0.1% (=1 g/l) 1.592

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 27622949

Title  Central Role of the Copper-Binding Motif in the Complex Mechanism of Action of Ixosin: Enhancing Oxidative Damage and Promoting Synergy with Ixosin B

Doi 10.1021/acsinfecdis.5b00140

Year  2016

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DBAASP ID  DBAASPR_17333

DCTPep is developed by Dr.Zheng's team.