LL-37 (17-29) [R23L,I24L,D26K,F27L]

General Information


DCTPep ID  DCTPep02881

Peptide Name   LL-37 (17-29) [R23L,I24L,D26K,F27L]

Sequence  FKRIVQLLKKLLR

Sequence Length  13

UniProt ID  P49913 

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

ACP Tumor active peptide



Activity Information


Cell Line Disease Activity Assay Testing Time Literature
A549 Lung adenocarcinoma IC50=12.8 μg/ml MTT assay 24 h 1

Hemolytic Activity  Human erythrocytes: HC50=411 µg/ml

Normal (non-cancerous) Cytotoxicity  DLF lung fibroblasts: IC50=23.7 μg/ml

Target  Not available

Affinity  Not available

Mechanism  Not available



Structure Information


PDB ID  Not available

Predicted Structure  DCTPep02881

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Amidation

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C79H143N23O15

Absent amino acids  ACDEGHMNPSTWY

Theoretical pI  12.02

Acidic residues  0

Basic residues  5

Polar residues  0

Molecular weight (Average)  1655.15

Molecular weight (Monoisotopic)  1654.11

Common amino acids  L

Net charge  5

Instability index (II)  17.97

Aliphatic index  172.31

Grand average of hydropathicity (GRAVY)  0.192

Half Life 
  1.1 hours (mammalian reticulocytes, in vitro).
  3 min (yeast, in vivo).
  2 min (Escherichia coli, in vivo).

Extinction coefficients 
  Should not be visible by UV spectrophotometry.

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 32567085

Title  Cationic amphipathic peptide analogs of cathelicidin LL-37 as a probe in the development of antimicrobial/anticancer agents

Doi 10.1002/psc.3254

Year  2020

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DBAASP ID  DBAASPS_17799

DCTPep is developed by Dr.Zheng's team.