Peptide Libraray

LL-37 (17-29) [R23L,I24L,D26K,F27L]-Ac

General Information

DCTPep ID DCTPep02882

Peptide Name LL-37 (17-29) [R23L,I24L,D26K,F27L]-Ac

Sequence FKRIVQLLKKLLR

Sequence Length 13

UniProt ID P49913

PubChem CID Not available

Origin Synthetic

Type Synthetic peptide

Classification

ACP Tumor active peptide

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
A549	Lung adenocarcinoma	IC50=9.8 μg/ml	MTT assay	24 h	1

Hemolytic Activity Human erythrocytes: HC50=185 µg/ml

Normal (non-cancerous) Cytotoxicity DLF lung fibroblasts: IC50=17.3 μg/ml

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure DCTPep02882

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Acetylation

C-terminal Modification Amidation

Other Modification None

Chiral L

Physicochemical Information

Formula C79H143N23O15

Absent amino acids ACDEGHMNPSTWY

Theoretical pI 12.02

Acidic residues 0

Basic residues 5

Polar residues 0

Molecular weight (Average) 1655.15

Molecular weight (Monoisotopic) 1654.11

Common amino acids L

Net charge 5

Instability index (II) 17.97

Aliphatic index 172.31

Grand average of hydropathicity (GRAVY) 0.192

Half Life
1.1 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
2 min (Escherichia coli, in vivo).

Extinction coefficients
Should not be visible by UV spectrophotometry.

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 32567085

Title Cationic amphipathic peptide analogs of cathelicidin LL-37 as a probe in the development of antimicrobial/anticancer agents

Doi 10.1002/psc.3254

Year 2020

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available

External Code

DBAASP ID DBAASPS_17800