This work is licensed under a Creative Commons Attribution 4.0 International License.
H-10, Hymenochirin-1B [E6,N10,A18,A22 S5]
General Information
DCTPep ID DCTPep02891
Peptide Name H-10, Hymenochirin-1B [E6,N10,A18,A22 S5]
Sequence IKLSPⓍTKDⓍLKKVLKGⓍIKGⓍIAVAKMV
Sequence Length 29
UniProt ID W8PRC4
PubChem CID Not available
Origin Synthetic (Derived from Hymenochirin-1B)
Type Synthetic peptide
Classification
ACP Tumor active peptide Stapled Peptides
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| HepG2 | Hepatoblastoma | IC50=1.50±0.21 μM | MTT assay | 96 h | 1 |
| HCT 116 | Colon carcinoma | IC50=3.51±0.37 μM | MTT assay | 96 h | 1 |
| A549 | Lung adenocarcinoma | IC50=3.59±0.12 μM | MTT assay | 96 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Stapled: Ⓧ(6) and Ⓧ (10), Ⓧ(18) and Ⓧ (22) are cross-linked by hydrocarbon stapling
N-terminal Modification Free
C-terminal Modification Free
Other Modification Ⓧ=(S)-N-Fmoc-2-(4′-pentenyl)alanine
Chiral L
Physicochemical Information
Formula Not Applicable
Absent amino acids Not Applicable
Theoretical pI Not Applicable
Acidic residues Not Applicable
Basic residues Not Applicable
Polar residues Not Applicable
Molecular weight (Average) Not Applicable
Molecular weight (Monoisotopic) Not Applicable
Common amino acids Not Applicable
Net charge Not Applicable
Instability index (II) Not Applicable
Aliphatic index Not Applicable
Grand average of hydropathicity (GRAVY) Not Applicable
Half Life
Not Applicable
Extinction coefficients
Not Applicable
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 30789695
Title Improving Selectivity, Proteolytic Stability, and Antitumor Activity of Hymenochirin-1B: A Novel Glycosylated Staple Strategy
Doi 10.1021/acschembio.9b00046
Year 2019
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_18014
This work is licensed under a Creative Commons Attribution 4.0 International License.