Peptide Libraray

Dermaseptin S4 (3-28)a

General Information

DCTPep ID DCTPep02905

Peptide Name Dermaseptin S4 (3-28)a

Sequence WMTLLKKVLKAAAKAALNAVLVGANA

Sequence Length 26

UniProt ID P80280

PubChem CID Not available

Origin Synthetic

Type Synthetic peptide

Classification

ACP Tumor active peptide

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
SW620	Colon adenocarcinoma	54.02±3.37% Cytotoxicity=256 µg/ml	MTT assay	3h	1

Hemolytic Activity Human erythrocytes: 68.5±7.58% Hemolysis=256 µg/ml

Normal (non-cancerous) Cytotoxicity Not available

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure DCTPep02905

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Amidation

Other Modification None

Chiral L

Physicochemical Information

Formula C123H213N33O30S1

Absent amino acids CDEFHIPQRSY

Theoretical pI 10.48

Acidic residues 0

Basic residues 4

Polar residues 4

Molecular weight (Average) 2666.31

Molecular weight (Monoisotopic) 2664.59

Common amino acids A

Net charge 4

Instability index (II) 1.29

Aliphatic index 139.23

Grand average of hydropathicity (GRAVY) 0.896

Half Life
2.8 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
2 min (Escherichia coli, in vivo).

Extinction coefficients
Ext. coefficient 5500
Abs 0.1% (=1 g/l) 2.063

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 33774792

Title Evaluating the effect of dermaseptin S4 and its derivatives on multidrug-resistant bacterial strains and on the colon cancer cell line SW620

Doi 10.1007/s11356-021-13683-2 Abstract

Year 2021

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available

External Code

DBAASP ID DBAASPS_18033