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sC18 [E15F]
General Information
DCTPep ID DCTPep02908
Peptide Name sC18 [E15F]
Sequence GLRKRLRKFRNKIKFK
Sequence Length 16
UniProt ID P25230
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Cell-penetrating peptides Membrane-targeted
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | Not active up to 40 µM | Resazurin assay | 24 h | 1 |
| MCF-7 | Invasive breast carcinoma of no special type | Not active up to 40 µM | Resazurin assay | 24 h | 1 |
Hemolytic Activity Human erythrocytes: <10% Hemolysis =40 µM
Normal (non-cancerous) Cytotoxicity HEK293: <10% Killing=40 µM
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure DCTPep02908
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C96H170N34O18
Absent amino acids ACDEHMPQSTVWY
Theoretical pI 12.49
Acidic residues 0
Basic residues 9
Polar residues 2
Molecular weight (Average) 2088.62
Molecular weight (Monoisotopic) 2087.34
Common amino acids K
Net charge 9
Instability index (II) 56.33
Aliphatic index 73.12
Grand average of hydropathicity (GRAVY) -1.481
Half Life
30 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).
Extinction coefficients
Should not be visible by UV spectrophotometry.
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 33313751
Title Multistep optimization of a cell-penetrating peptide towards its antimicrobial activity
Year 2021
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_18141
This work is licensed under a Creative Commons Attribution 4.0 International License.