This work is licensed under a Creative Commons Attribution 4.0 International License.
sC18 [R10,K16 4-F-Phe,E15Del]
General Information
DCTPep ID DCTPep02916
Peptide Name sC18 [R10,K16 4-F-Phe,E15Del]
Sequence GLRKRLRKFXNKIKX
Sequence Length 15
UniProt ID P25230
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
ACP Tumor active peptide Cell-penetrating peptides Membrane-targeted
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | >80% Killing=40 µM | Resazurin assay | 24 h | 1 |
| MCF-7 | Invasive breast carcinoma of no special type | >90% Killing=40 µM | Resazurin assay | 24 h | 1 |
Hemolytic Activity Human erythrocytes: <10% Hemolysis =40 µM
Normal (non-cancerous) Cytotoxicity HEK293: <10% Killing=40 µM
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification X=4-F-Phe
Chiral L
Physicochemical Information
Formula Not Applicable
Absent amino acids Not Applicable
Theoretical pI Not Applicable
Acidic residues Not Applicable
Basic residues Not Applicable
Polar residues Not Applicable
Molecular weight (Average) Not Applicable
Molecular weight (Monoisotopic) Not Applicable
Common amino acids Not Applicable
Net charge Not Applicable
Instability index (II) Not Applicable
Aliphatic index Not Applicable
Grand average of hydropathicity (GRAVY) Not Applicable
Half Life
Not Applicable
Extinction coefficients
Not Applicable
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 33313751
Title Multistep optimization of a cell-penetrating peptide towards its antimicrobial activity
Year 2021
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_18149
This work is licensed under a Creative Commons Attribution 4.0 International License.