This work is licensed under a Creative Commons Attribution 4.0 International License.
Phakellistatin 15
General Information
DCTPep ID DCTPep02919
Peptide Name Phakellistatin 15
Sequence PWIPLTPL
Sequence Length 8
UniProt ID Not available
PubChem CID 46209786
Origin Phakellia fusca
Type Native peptide
Classification
ACP Tumor active peptide
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| P388 | Mouse lymphoma | IC50=8.5 μM | MTT assay | 48 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond NCB: Pro1<--->Leu8
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C48H73N9O10
Absent amino acids ACDEFGHKMNQRSVY
Theoretical pI 5.96
Acidic residues 0
Basic residues 0
Polar residues 1
Molecular weight (Average) 936.16
Molecular weight (Monoisotopic) 935.55
Common amino acids P
Net charge 0
Instability index (II) 1.55
Aliphatic index 146.25
Grand average of hydropathicity (GRAVY) 0.713
Half Life
>20 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
? (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 5500
Abs 0.1% (=1 g/l) 5.875
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 20345147
Title Proline-containing cyclopeptides from the marine sponge Phakellia fusca
Year 2010
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPN_18416
This work is licensed under a Creative Commons Attribution 4.0 International License.