Peptide Libraray

Phakellistatin 16

General Information

DCTPep ID DCTPep02920

Peptide Name Phakellistatin 16

Sequence PFDSRAVTY

Sequence Length 9

UniProt ID Not available

PubChem CID 44250811

Origin Phakellia fusca

Type Native peptide

Classification

ACP Tumor active peptide

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
BEL-7402	Human papillomavirus-related endocervical adenocarcinoma	IC50=14.3 μM	MTT assay	48 h	1
P388	Mouse lymphoma	IC50=5.4 μM	MTT assay	48 h	1

Hemolytic Activity Not available

Normal (non-cancerous) Cytotoxicity Not available

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Cyclic

Disulfide/Other Bond NCB: Pro1<--->Tyr9

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Chiral L

Physicochemical Information

Formula C48H70N12O15

Absent amino acids CEGHIKLMNQW

Theoretical pI 6.26

Acidic residues 1

Basic residues 1

Polar residues 3

Molecular weight (Average) 1055.16

Molecular weight (Monoisotopic) 1054.51

Common amino acids ADFPRSTVY

Net charge 0

Instability index (II) 77.37

Aliphatic index 43.33

Grand average of hydropathicity (GRAVY) -0.400

Half Life
>20 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
? (Escherichia coli, in vivo).

Extinction coefficients
Ext. coefficient 1490
Abs 0.1% (=1 g/l) 1.412

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 20345147

Title Proline-containing cyclopeptides from the marine sponge Phakellia fusca

Doi 10.1021/np9008267

Year 2010

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available

External Code

DBAASP ID DBAASPN_18415