Peptide Libraray

Phakellistatin 19

General Information

DCTPep ID DCTPep02923

Peptide Name Phakellistatin 19

Sequence IPWFPLTP

Sequence Length 8

UniProt ID Not available

PubChem CID 57335467

Origin Phakellia fusca

Type Native peptide

Classification

ACP Tumor active peptide

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
A549	Lung adenocarcinoma	IC50=0.44 µM	MTT assay	8 h	1
HT-29	Colon adenocarcinoma	IC50=0.462 µM	MTT assay	8 h	1
MDA-MB-231	Breast adenocarcinoma	IC50=0.515 µM	MTT assay	8 h	1

Hemolytic Activity Not available

Normal (non-cancerous) Cytotoxicity Not available

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Cyclic

Disulfide/Other Bond NCB: Ile1<--->Pro8

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Chiral L

Physicochemical Information

Formula C51H71N9O10

Absent amino acids ACDEGHKMNQRSVY

Theoretical pI 5.52

Acidic residues 0

Basic residues 0

Polar residues 1

Molecular weight (Average) 970.18

Molecular weight (Monoisotopic) 969.53

Common amino acids P

Net charge 0

Instability index (II) 25.62

Aliphatic index 97.50

Grand average of hydropathicity (GRAVY) 0.588

Half Life
20 hours (mammalian reticulocytes, in vitro).
30 min (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).

Extinction coefficients
Ext. coefficient 5500
Abs 0.1% (=1 g/l) 5.669

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 24252114

Title Rescuing biological activity from synthetic phakellistatin 19

Doi 10.1021/jm401520x

Year 2013

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available

External Code

DBAASP ID DBAASPN_18419