Peptide Libraray

Phakellistatin 2

General Information

DCTPep ID DCTPep02927

Peptide Name Phakellistatin 2

Sequence IxPYPFP

Sequence Length 7

UniProt ID Not available

PubChem CID 101663073

Origin Stylotella aurantium

Type Native peptide

Classification

ACP Tumor active peptide

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
A549	Lung adenocarcinoma	IC50=0.66 µM	SRB assay	Not available	2
HCT 116	Colon carcinoma	IC50=0.71 µM	SRB assay	Not available	2
SK-HEP-1	Liver and intrahepatic bile duct epithelial neoplasm	IC50=0.77 µM	SRB assay	Not available	2
MDA-MB-231	Breast adenocarcinoma	IC50=1.3 µM	SRB assay	Not available	2
SNU-638	Gastric adenocarcinoma	IC50=1.6 µM	SRB assay	Not available	2
A2780	Ovarian endometrioid adenocarcinoma; Endometrioid carcinoma of ovary	IC50=28.27 µg/ml (DMSO); IC50=2.72 µg/ml (MeOH)	SRB assay	Not available	1
K562	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive; Chronic myeloid leukemia	IC50=3.2 µM	SRB assay	Not available	2

Hemolytic Activity Not available

Normal (non-cancerous) Cytotoxicity Not available

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Cyclic

Disulfide/Other Bond NCB: Ile1<--->Pro7

N-terminal Modification Free

C-terminal Modification Free

Other Modification x=D-Allo-Ile

Chiral Mix

Physicochemical Information

Formula Not Applicable

Absent amino acids Not Applicable

Theoretical pI Not Applicable

Acidic residues Not Applicable

Basic residues Not Applicable

Polar residues Not Applicable

Molecular weight (Average) Not Applicable

Molecular weight (Monoisotopic) Not Applicable

Common amino acids Not Applicable

Net charge Not Applicable

Instability index (II) Not Applicable

Aliphatic index Not Applicable

Grand average of hydropathicity (GRAVY) Not Applicable

Half Life
Not Applicable

Extinction coefficients
Not Applicable

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 12444643

Title Two distinct conformers of the cyclic heptapeptide phakellistatin 2 isolated from the fijian marine sponge stylotellaaurantium

Doi 10.1021/jo020482s

Year 2002

Literature 2

Pubmed ID 29893558

Title Cyclopeptides from the Sponge Stylissa flabelliformis

Doi 10.1021/acs.jnatprod.8b00121

Year 2018

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available

External Code

DBAASP ID DBAASPN_18423